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  • Title: Contact allergy to the active ingredients of Kathon CG.
    Author: Bruze M, Dahlquist I, Fregert S, Gruvberger B, Persson K.
    Journal: Contact Dermatitis; 1987 Apr; 16(4):183-8. PubMed ID: 3595116.
    Abstract:
    The preservative Kathon CG is a commercial preparation, consisting of 2 active ingredients and other components. 28 patients with contact allergy to Kathon CG participated in a study in which patch testing was performed with serial dilutions, and with 5 chromatographically separated fractions. All reacted to fraction IV, and 2 patients also to fraction II. Mass spectrometry and nuclear magnetic resonance spectrometry identified fraction II and IV to be the active ingredients; 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one.
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