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  • Title: Increase by 5-hydroxykynuramine of spontaneous acetylcholine release from myenteric neurons: mediated by serotonin M receptors.
    Author: Pfeuffer-Friederich I, Kilbinger H, Back W.
    Journal: Eur J Pharmacol; 1987 Apr 14; 136(2):225-9. PubMed ID: 3595721.
    Abstract:
    The effects of 5-hydroxykynuramine (5-OH-K) and of 3-(2-amino-5-hydroxyphenyl)-propaneamine (AHPP) on spontaneous and electrically evoked release of [3H]acetylcholine were studied in the guinea-pig myenteric plexus longitudinal muscle preparation preincubated with [3H]choline. 5-OH-K caused a concentration-dependent increase in spontaneous [3H]acetylcholine release (EC50 5.3 microM). This effect was diminished in the presence of a desensitizing concentration of 5-hydroxytryptamine (5-HT). AHPP (1-100 microM) did not affect the spontaneous outflow of [3H]acetylcholine. The electrically evoked release of [3H]acetylcholine was significantly reduced in the presence of 100 microM of either 5-OH-K or AHPP. Metitepine did not antagonize the inhibition, which suggests that 100 microM of either compound non-specifically depressed the evoked release. It is concluded that 5-OH-K is inactive at the release-inhibitory 5-HT1 receptor, but is a potent agonist at the M receptor of myenteric neurons.
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