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  • Title: Determination of valproic acid (dipropylacetic acid) in plasma by gas-liquid chromatography.
    Author: Berry DJ, Clarke LA.
    Journal: J Chromatogr; 1978 Sep 11; 156(2):301-7. PubMed ID: 359583.
    Abstract:
    A specific and sensitive procedure for the determination of valproic acid at therapeutic concentrations in human plasma has been developed. The method involves a microscale extraction of the drug from acidified plasma into chloroform. Caproic acid is added as internal standard. The extract is subsequently analysed on a gas chromatography fitted with a flame ionisation detector, and quantitation achieved by the relative-peak-height technique.
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