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  • Title: Penetration of cefonicid in skin suction blister fluid in healthy volunteers.
    Author: Cruciani M, Concia E, Passarella E, Soncini R.
    Journal: Int J Clin Pharmacol Res; 1987; 7(3):225-7. PubMed ID: 3596863.
    Abstract:
    A new cephalosporin, cefonicid (1 g) was given intramuscularly to six healthy volunteers 12 h after induction of skin suction blister. Serum and blister fluid were collected during a 24 h period. Antibiotic assay was made by a microbiological method. The data were analysed by a one-compartment kinetic model. Despite the high protein binding, cefonicid penetrated in microbiologically effective concentration into blister fluid. Blister fluid concentrations were higher than the serum concentrations at 24 h.
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