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  • Title: Organo/Silver Dual Catalytic (3 + 2)/Conia-Ene Type Cyclization: Asymmetric Synthesis of Indane-Fused Spirocyclopenteneoxindoles.
    Author: Li DA, He XH, Tang X, Wu Y, Zhao H, He G, Peng C, Han B, Zhan G.
    Journal: Org Lett; 2022 Aug 26; 24(33):6197-6201. PubMed ID: 35976152.
    Abstract:
    Developing efficient strategies to synthesize spirocyclopenteneoxindoles is an attractive target due to their potential biological activity. This work described the thiourea/silver dual catalytic (3 + 2)/Conia-ene type reaction of 2-(2-oxoindolin-3-yl)malononitrile with ortho-ethynyl substituted nitrostyrene. The reaction features mild conditions and good atom- and step-economy. Three new C-C bonds were formed within one synthetic step, providing the indane-fused spirocyclopenteneoxindoles in good yields, with excellent chemo-, regio-, and stereoselectivity.
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