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  • Title: The paradoxical adverse effect of verapamil for treating clinical paroxysmal supraventricular tachycardia.
    Author: Saikawa T, Inoue K, Ohmura I, Ito S, Yonemochi H, Nakagawa M, Ito M, Ohashi K, Ebihara A.
    Journal: Jpn Heart J; 1987 Jan; 28(1):107-13. PubMed ID: 3599396.
    Abstract:
    The intravenous administration of verapamil to 2 patients with paroxysmal supraventricular tachycardia (PSVT) resulted in an induction of PSVT during a programmed electrophysiological stimulation study. Each patient had a documented episode of PSVT. Baseline programmed stimulation studies revealed neither induction of PSVT nor an atrial echo; however, PSVT was induced immediately after injecting verapamil (0.15 mg/kg) intravenously in both patients. In 1 patient, the study was repeated 2 days later and similar results were obtained. The serum concentration of verapamil when PSVT was induced was about 80 ng/ml in both cases. Clinicians using verapamil should note that this antiarrhythmic drug may aggravate PSVT, depending on critical changes in AV nodal conduction and refractoriness.
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