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  • Title: Direct effects of biguanides on glucose utilization in vitro.
    Author: Purrello F, Gullo D, Brunetti A, Buscema M, Italia S, Goldfine ID, Vigneri R.
    Journal: Metabolism; 1987 Aug; 36(8):774-6. PubMed ID: 3600289.
    Abstract:
    The effect of the biguanides metformin and phenformin on glucose utilization in isolated cells was studied with IM-9 human lymphocytes. Both agents stimulated glucose consumption from the incubation media. Detectable effects of metformin were seen at 33 mumol/L and detectable effects of phenformin were seen at 1.7 mumol/L. Both agents, at similar concentrations, also stimulated [3H] 2-deoxy-D-glucose uptake. Studies with phenformin indicated that biguanides increase the Vmax of uptake without changing the Km. In contrast to the biguanides, IM-9 cells insulin did not influence either glucose consumption or [3H] 2-deoxy-D-glucose uptake. These data provide evidence, therefore, that biguanides may directly influence the cellular utilization of glucose.
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