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  • Title: Effects of dipalmitoylphosphatidylcholine liposomes on high affinity transport of choline and synthesis of acetylcholine in cerebral cortical synaptosomes in the rat.
    Author: Bottiglieri DF, Meyer EM.
    Journal: Neuropharmacology; 1987 May; 26(5):453-6. PubMed ID: 3601005.
    Abstract:
    The presynaptic cholinergic effects of the phospholipid dipalmitoylphosphatidylcholine were investigated in non-depolarized synaptosomes from the cerebral cortex of the rat. This naturally-occurring phospholipid, in the form of small unilamellar vesicles (3.0 mg/ml), inhibited both high affinity uptake of [3H] choline and the synthesis of [3H] acetylcholine. This lipid-induced inhibition was apparently competitive, since it was observed at 1 microM but not 20 microM extracellular concentration of choline. These results indicate that dipalmitoylphosphatidylcholine may reduce the synthesis of acetylcholine in resting nerve terminals.
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