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  • Title: [Determination and interpretation of in vitro solubility behavior of pharmaceutical agents. 2. The effect of surface tension of the dissolution medium on the liberation of drugs in commercial preparations (tablets, dragees)].
    Author: Bornschein M, Eitz K, Voigt R.
    Journal: Pharmazie; 1987 Feb; 42(2):83-6. PubMed ID: 3602064.
    Abstract:
    The influence of submicellar surfactants in the dissolution media on drug liberation from commercial products was investigated (paddle-method, flow through-method). The results depend on the product tested and the tester used. Addition of surfactants accelerates, retards or doesn't alter in vitro liberation with the paddle-method, accelerates or doesn't influence flow through-liberation. Equivalence of the release profiles of the individual products with both testers was proved. Addition of surfactants may alter in vitro drug release from commercial products but should be compulsory only when (improved) in vivo-in vitro correlation was demonstrated.
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