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  • Title: Pharmaceutical availability from oral dosage forms: in vitro release of nitrofurantoin from tablets and capsules.
    Author: Senjković R, Kallay N, Vilendecić M.
    Journal: Pharmazie; 1987 Mar; 42(3):186-8. PubMed ID: 3602077.
    Abstract:
    The pharmaceutical availability of nitrofurantoin in three commercial urinary antiseptic preparations for oral use was assessed by an in vitro determination of drug release into a strongly acidic, a weakly acidic and a weakly basic medium. The following parameters are reported: t87.5%, tdiss, X0 (percentage released immediately on contact with medium), krel (relative dissolution rate constant), and dissolution efficiency (DE).
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