These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inhibited drinking and pica in rats following 2-deoxy-D-glucose.
    Author: Watson PJ, Hawkins C, McKinney J, Beatey S, Bartles RR, Rhea K.
    Journal: Physiol Behav; 1987; 39(6):745-52. PubMed ID: 3602128.
    Abstract:
    A sequence of studies sought to determine if 2-deoxy-D-glucose (2DG) produces malaise as a side effect. Drug treatment at dosages at least as low as 250 mg/kg triggered an immediate inhibition of fluid intake. In nondeprived animals, 750 mg/kg but not lower dosages of 2DG evoked a delayed but statistically significant level of pica as measured by kaolin consumption. Twenty-four hour food deprivation failed to produce pica, and previous claims that kaolin intake is a specific index of gastrointestinal distress therefore received additional support. Thirsty rats injected with 750 mg/kg 2DG displayed a delayed pattern of pica largely similar to that previously observed with undeprived subjects; although, under optimal circumstances, significant increases in kaolin consumption may be evident as soon as one hour post-injection. In general, these data indicated that malaise may be an important influence of 2DG; but dosage and time course parameters associated with post-drug reductions in drinking suggested that a separable consummatory inhibition effect may also occur.
    [Abstract] [Full Text] [Related] [New Search]