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  • Title: Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium.
    Author: Skopek TR, Liber HL, Kaden DA, Thilly WG.
    Journal: Proc Natl Acad Sci U S A; 1978 Sep; 75(9):4465-9. PubMed ID: 360221.
    Abstract:
    Forward mutation to 8-azaguanine resistance and reverse mutation to histidine prototrophy were measured in Salmonella typhimurium after treatment with 16 mutagens of both base-substitution and frameshift classes. The two approaches were found to be equisensitive for all 16 mutagens--i.e., induction of significant mutation occurred at similar concentrations in the forward mutation assay and in the most sensitive of the five Ames tester strains.
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