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  • Title: Influence of heart rate on metabolic and hemodynamic parameters in the Syrian hamster cardiomyopathy.
    Author: Markiewicz W, Wu S, Sievers R, Parmley WW, Higgins CB, James TL, Jasmin G, Wikman-Coffelt J.
    Journal: Am Heart J; 1987 Aug; 114(2):362-8. PubMed ID: 3604893.
    Abstract:
    The effect of varying heart rate in 155- to 170-day-old isolated, perfused cardiomyopathic Syrian hamster hearts was evaluated by 31P nuclear magnetic resonance spectroscopy. At a low paced heart rate of 170 bpm, cardiomyopathic hearts did not differ from normal hearts except for a lower developed left ventricular pressure. As pacing rate was increased progressively to 270/min, cardiomyopathic hearts showed prolongation of contraction, which led to a pronounced rise in diastolic pressure as the interstimulus interval shortened. This was accompanied by a marked decrease in energy-rich phosphorus compounds. By contrast, increasing heart rate in normal hearts did not change left ventricular pressure and caused only a mild reduction in energy-rich phosphorus compounds. Intracellular pH of cardiomyopathic animals paced at 270 bpm was significantly lower than in normal animals. Thus, indices reflecting mitochondrial function of 155- to 170-day-old cardiomyopathic hamsters appear adequate at low heart rate. Increasing the heart rate unmasks latent mitochondrial dysfunction.
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