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  • Title: Cryptococcosis associated with low-dose methotrexate for arthritis.
    Author: Altz-Smith M, Kendall LG, Stamm AM.
    Journal: Am J Med; 1987 Jul; 83(1):179-81. PubMed ID: 3605168.
    Abstract:
    One patient with psoriatic arthritis and a second with rheumatoid arthritis were each treated with low-dose methotrexate (10 to 15 mg per week, orally) for more than a year before pulmonary cryptococcosis developed. These are the first case reports of opportunistic fungal disease during this treatment. Low-dose methotrexate may be more immunosuppressive than has been appreciated. Patients demonstrating pneumonitis while receiving this therapy should be carefully evaluated to rule out an infectious cause.
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