These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Epidural anesthesia with bupivacaine: effects of age on neural blockade and pharmacokinetics.
    Author: Veering BT, Burm AG, van Kleef JW, Hennis PJ, Spierdijk J.
    Journal: Anesth Analg; 1987 Jul; 66(7):589-93. PubMed ID: 3605667.
    Abstract:
    Effects of aging after epidural administration of 0.5% bupivacaine without epinephrine were studied in two groups of patients, between 20 and 55 yr old and older than 55 yr, respectively. All patients received 95 mg bupivacaine HCl. The onset of analgesia in caudad segments decreased with age and the upper level of analgesia increased with age. Effects of age on duration of anesthesia could not be demonstrated. The total plasma clearance of bupivacaine decreased and the terminal half-life increased with age. Age had no effect on the peak plasma concentrations and time to peak concentrations.
    [Abstract] [Full Text] [Related] [New Search]