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  • Title: Effect of 1,1,1-trichloroethane inhalation on heart rate and its mechanism: a role of autonomic nervous system.
    Author: Kobayashi H, Hobara T, Kawamoto T, Sakai T.
    Journal: Arch Environ Health; 1987; 42(3):140-3. PubMed ID: 3606210.
    Abstract:
    The response of heart rate to acute 1,1,1-trichloroethane (1,1,1-TCE) inhalation and its mechanism via the autonomic nervous system were studied in anesthetized dogs in acute inhalation experiments. Concentrations of 1,1,1-TCE in inspired air of 1.32 +/- 0.14% (mean +/- S.E.) increased heart rate, but 2.79 +/- 0.24% decreased heart rate. Opposite reactions of heart rate were observed when blood pressure decreased to 70-80 mm Hg following inhalation. Moreover, both tachycardia from relatively low concentrations and bradycardia from higher concentrations were blocked by pre-administration of adrenergic beta blocker, but were only slightly affected by vagotomy. It is suggested that both tachycardia and bradycardia following 1,1,1-TCE inhalation may be controlled by the sympathetic nervous system.
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