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  • Title: A comparison of the hemodynamic responses of systematic and uteroplacental vasculature to angiotensin in conscious guinea pigs.
    Author: Hariharan S, Tseng H, Myers SA.
    Journal: Am J Perinatol; 1987 Jul; 4(3):235-9. PubMed ID: 3606756.
    Abstract:
    Hemodynamic studies were performed in 11 conscious pregnant guinea pigs using radioactive microspheres to calculate the effects of angiotensin II (AII) infusion. A dose-dependent increase of the mean arterial pressure and systemic vascular resistance during AII infusion was observed. A significant increase in in uteroplacental flow also occurred without a change in cardiac output or uteroplacental vascular resistance. These data demonstrate that the systemic and uterine vasculatures of the pregnant guinea pig have different responses to AII infusion.
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