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  • Title: Treatment of paramyotonia congenita with acetazolamide.
    Author: Benstead TJ, Camfield PR, King DB.
    Journal: Can J Neurol Sci; 1987 May; 14(2):156-8. PubMed ID: 3607618.
    Abstract:
    Treatment of paramyotonia congenita with acetazolamide has been shown to reduce myotonic symptoms but severe weakness has developed in some patients leading to a recommendation not to use the drug in this disorder. We studied a patient with the characteristic clinical and electrophysiological profile of paramyotonia congenita. Myotonia was effectively treated with a very low dose of acetazolamide and no weakness developed. We conclude that acetazolamide can be a safe and effective medication in paramyotonia congenita.
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