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  • Title: Clinical outcomes according to timing to invasive ventilation due to noninvasive ventilation failure in children.
    Author: Bustos-Gajardo FD, Luarte-Martínez SI, Dubo Araya SA, Adasme Jeria RS.
    Journal: Med Intensiva (Engl Ed); 2023 Feb; 47(2):65-72. PubMed ID: 36089512.
    Abstract:
    OBJECTIVE: Noninvasive ventilation (NIV) failure it has been associated to worst clinical outcomes due to a delay in intubation and initiation of invasive mechanical ventilation (IMV). There is a lack of evidence in pediatric patients regarding this topic. The objective was to deter-mine the association between duration of IMV and length of stay, with duration of NIV prior tointubation/IMV in pediatric patients. DESIGN: A prospective cohort study since January 2015 to October 2019. SETTING: A pediatric intensive care unit. PATIENTS: Children under 15 years with acute respiratory failure who failed to noninvasive ventilation. INTERVENTIONS: None. MAIN VARIABLES OF INTEREST: Demographic variables, pediatric index of mortality (PIM2), pediatric acute respiratory distress syndrome (PARDS) diagnosis, IMV and NIV duration, PICU LOS were registered and intrahospital mortality. RESULTS: A total of 109 patients with a median (IQR) age of 7 (3-14) months were included. The main diagnosis was pneumonia (89.9%). PARDS was diagnosed in 37.6% of the sample. No association was found between NIV duration and duration of IMV after Kaplan-Meier analysis (Log rank P = .479). There was no significant difference between PICU LOS (P = .253) or hospital LOS (P = 0.669), when categorized by NIV duration before intubation. PARDS diagnosis was associated to an increased length of invasive ventilation (HR: 0.64 [95% IC: 0.42-0.99]). CONCLUSIONS: No association was found between NIV duration prior to intubation and duration of invasive ventilation in critical pediatric patients with acute respiratory failure.
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