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  • Title: Hearing Loss After the First Low Dose Administration of Cisplatin.
    Author: Yildirim A, Fidan E, Ozdemir F.
    Journal: J Coll Physicians Surg Pak; 2022 Sep; 32(9):1216-1218. PubMed ID: 36089725.
    Abstract:
    Cisplatin is commonly used antineoplastic drug that is effective against different types of tumours. Nephrotoxicity, neurotoxicity, and ototoxicity constitute the main dose-limiting side effects of the drug. We present a case of sensorineural hearing loss after the first low dose of cisplatin. Five days after receiving an intravenous 30 mg/day at 120 minutes, the patient presented with serious bilateral sensorineural hearing loss. Cisplatin-induced hearing impairment is generally dose-related and cumulative; however, the toxicity can occur after the first dose without a cumulative high-dose and can be irreversible. Key Words: Cisplatin, Hearing Loss, Ototoxicity.
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