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  • Title: Adenosine receptor agonists inhibit inositol phosphate accumulation in rat striatal slices.
    Author: Petcoff DW, Cooper DM.
    Journal: Eur J Pharmacol; 1987 Jun 04; 137(2-3):269-71. PubMed ID: 3609145.
    Abstract:
    The accumulation of inositol-1-phosphate in rat striatal slices was inhibited by the adenosine analogues 5'-N-ethylcarboxamide-adenosine and N6-phenylisopropyladenosine. Maximal inhibition (approximately 20%) was achieved by micromolar concentrations of either compound. Both basal and stimulated values could be inhibited, and the inhibition was reversible by the adenosine receptor antagonist 8-phenyltheophylline (10 microM). The results suggest that adenosine may exert a tonic inhibitory influence on inositol phospholipid-derived second messenger production in the striatum in vivo.
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