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  • Title: Inhibition of induced acute lung edema by a novel protein kinase C inhibitor.
    Author: Struhar D, Harbeck RJ.
    Journal: FASEB J; 1987 Aug; 1(2):116-8. PubMed ID: 3609609.
    Abstract:
    The effect of the protein kinase C enzyme inhibitor H-7 on the noncardiogenic lung edema induced by phorbol myristate acetate (PMA) in mice was examined. Lung edema was assessed by measurement of 125I-labeled albumin leak into the lung. The results showed that pretreatment of mice with H-7 nearly prevents the albumin leak induced by PMA, whereas post-PMA treatment with H-7 had less of an effect on the albumin leak, although it was still significant.
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