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Title: Study of the metabolic effects of bunitrolol (Koe 1366) in angina induced by catecholamine infusion. Author: Cuccurullo F, Masi M, Mezzetti A, Rosini R, Luciani G, Tomassetti V, Abate G, Lenzi S. Journal: Arzneimittelforschung; 1979; 29(1):138-41. PubMed ID: 36102. Abstract: In ten angina patients responding with a myocardial anaerobic metabolic pattern to isoproterenol infusion, a new beta-blocking agent, bunitrolol, was effective in normalizing the myocardial lactate extraction ratio. The correlation with lipid metabolism was also interesting because beta-blocker action reduced significantly arterial non-esterified fatty acids (NEFA) level as well as myocardial NEFA extraction. The metabolic behavior suggests the effectiveness of bunitrolol in the treatment of ischemic heart disease.[Abstract] [Full Text] [Related] [New Search]