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  • Title: Liver takes up retinol-binding protein from plasma.
    Author: Gjøen T, Bjerkelund T, Blomhoff HK, Norum KR, Berg T, Blomhoff R.
    Journal: J Biol Chem; 1987 Aug 15; 262(23):10926-30. PubMed ID: 3611097.
    Abstract:
    Retinol is transported in plasma bound to a specific transport protein, retinol-binding protein. We prepared 125I-tyramine cellobiose-labeled rat retinol-binding protein and studied its tissue uptake 1, 5, and 24 h after intravenous injection into rats. The liver was the organ containing most radioactivity at all time points studied. After 5 and 24 h, 30 and 22% of the injected dose were recovered in liver, respectively. After separating the liver into parenchymal and nonparenchymal cells in the 5-h group, we found that both cell fractions contained approximately the same amount of radioactivity (per gram of liver). Most of the retinol-binding protein radioactivity in the nonparenchymal cell fraction was in the stellate cells. The implication of these results for a possible transfer mechanism for retinol between parenchymal and stellate cells is discussed.
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