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  • Title: NCOA4: More than a receptor for ferritinophagy.
    Author: Wang Z, Zhang H.
    Journal: J Cell Biol; 2022 Oct 03; 221(10):. PubMed ID: 36112419.
    Abstract:
    Liquid-liquid phase separation (LLPS) triages protein cargoes for autophagic degradation. In this issue, Ohshima et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203102) demonstrate that the autophagy receptor NCOA4 interacts with ferritin particles to form liquid-like condensates via LLPS. The NCOA4-ferritin condensates are delivered to lysosomes for degradation via either canonical macroautophagy or endosomal microautophagy to maintain intracellular iron homeostasis.
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