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  • Title: Effects of maternal indomethacin administration on fetal breathing movements in sheep.
    Author: Patrick J, Challis JR, Cross J.
    Journal: J Dev Physiol; 1987 Jun; 9(3):295-300. PubMed ID: 3611641.
    Abstract:
    To determine the role of prostaglandins in the control of fetal breathing movements, we infused indomethacin (5 mg/ml; 25 mg/kg per day) into the maternal femoral vein for 70 h in 5 pregnant ewes. There was a significant increase in the incidence and amplitude of fetal breathing movements beginning within 2 h reaching a peak at 8-10 h. It then diminished and was no longer present by 20-70 h despite continued indomethacin infusion. Maternal glucose concentrations were increased at 8 and 16 h following the initiation of indomethacin infusion. The data suggested that the previously reported effects of cyclo-oxygenase inhibitor on fetal breathing movements are transient and do not continue beyond 20 h.
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