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  • Title: Effect of arginine vasopressin on arterial oxygen partial pressure in the chronically catheterized fetal lamb.
    Author: Bessho T, Murata Y, Ibara S, Tyner JG, Keegan KA, Porto M, Schmidt PL.
    Journal: Nihon Sanka Fujinka Gakkai Zasshi; 1987 Jun; 39(6):995-7. PubMed ID: 3611875.
    Abstract:
    Fetal plasma 2,3-Diphosphoglycerate (2,3-DPG) and glucose levels were observed during infusion of arginine vasopressin into 6 chronically catheterized fetal lambs. Low dose infusion of arginine vasopressin (5-10 mIU/min.) did not change fetal arterial blood gases significantly. At a high concentration of vasopressin (20-40 mIU/min.), infusion for 60 minutes increased fetal arterial pO2 by approximately 5 mmHg (p less than 0.005 by paired t-test), and decreased pCO2 by approximately 2 mmHg (p less than 0.005 by paired t-test) without significant changes in pH. Neither low nor high dose infusion of arginine vasopressin was accompanied by significant changes in 2,3-DPG or the glucose level.
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