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  • Title: Synthesis and insecticidal activities of 4-(propargyloxy) benzenesulfonamide derivatives.
    Author: Zhou B, Liu LL, Zhao WY, Han LJ, Li AJ, Zhao C, Wu WJ, Zhang JW.
    Journal: J Asian Nat Prod Res; 2023 Jun; 25(6):571-580. PubMed ID: 36125926.
    Abstract:
    A series of 4-(propargyloxy) benzenesulfonamide derivatives with different substituents on the benzene ring were synthesized and evaluated for their insecticidal activity. Some of the compounds showed good insecticidal activity against Mythimna separata, and the LC50 value of the most active compound B2.5 was 0.235 mg/ml. Ultrastructural changes in the midgut epithelial cells of Mythimna separata were observed using transmission electron microscopy, and severe structural damage was found in microvilli, mitochondria and rough endoplasmic reticulum. It indicates that the possible site of action of these benzenesulfonamides is the cytoplasmic membrane and endomembrane system of the midgut epithelial cells. The above provides a basis for the development of novel insecticidal active compounds with a novel mechanism of action.
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