These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Aldosterone antagonists. 2. New 7 alpha-(acetylthio)-15,16-methylene spirolactones.
    Author: Nickisch K, Bittler D, Laurent H, Losert W, Casals-Stenzel J, Nishino Y, Schillinger E, Wiechert R.
    Journal: J Med Chem; 1987 Aug; 30(8):1403-9. PubMed ID: 3612688.
    Abstract:
    Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone were synthesized with the purpose of increasing the antialdosterone potency and reducing the endocrinological effects of this standard compound. By introduction of a 1,2-double bond and a 15 beta,16 beta-methylene ring in the spironolactone molecule both goals were achieved. In animal studies mespirenone exhibited a threefold-greater antialdosterone potency and less than 10% of the antiandrogenic activity of spironolactone.
    [Abstract] [Full Text] [Related] [New Search]