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  • Title: Wolf-Hirschhorn locus is distal to D4S10 on short arm of chromosome 4.
    Author: McKeown C, Read AP, Dodge A, Stecko O, Mercer A, Harris R.
    Journal: J Med Genet; 1987 Jul; 24(7):410-2. PubMed ID: 3612716.
    Abstract:
    We report a family in which Wolf-Hirschhorn syndrome in two children with partial monosomy of the short arm of chromosome 4 is the result of unbalanced segregation of a reciprocal 4;12 translocation in the mother. Studies with the DNA probe G8 show that the translocation breakpoint in this family is distal to the D4S10 locus. Previously reported cases of Wolf-Hirschhorn syndrome have involved the deletion of D4S10. These observations may prove helpful in the search for better genetic markers for Huntington's chorea, which maps close to D4S10.
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