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  • Title: Hemodynamic and echocardiographic evaluation of the stumptailed macaque: a potential nonhuman primate model for pulmonary vascular disease.
    Author: Weesner KM, Kaplan K.
    Journal: J Med Primatol; 1987; 16(3):185-202. PubMed ID: 3612762.
    Abstract:
    Stumptailed macaques (Macaca arctoides) were evaluated as to their suitability as an animal model for pulmonary hypertension. Animals used for this study were colony-bred. Necropsy material from 63 animals revealed 32% with severe medial thickening of pulmonary arteries. Twenty-nine stumptailed macaques underwent cardiac catheterization and M-mode echocardiography. Hemodynamic measurement including pulmonary artery pressure response to 12% oxygen exposure identified three groups of animals with elevated, normal, and intermediate pulmonary artery pressures. Stumptailed macaques with elevated pulmonary artery pressure could be distinguished from other animals by echocardiography.
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