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  • Title: Antagonism by naloxone of anti-tremorine effect of bromocriptine in mice.
    Author: Shukla VK, Garg SK, Kulkarni SK.
    Journal: Methods Find Exp Clin Pharmacol; 1987 May; 9(5):303-6. PubMed ID: 3613759.
    Abstract:
    Effects of the opioid antagonist naloxone (10 mg/kg) and its interaction with anticholinergic (scopolamine) and dopaminergic (bromocriptine) agents against tremorine-induced tremors was studied. Naloxone (10 mg/kg) per se gave significant protection and significantly potentiated the protective effect of scopolamine against tremorine-induced tremors at 5 min only. When naloxone and subeffective dose of bromocriptine (2 mg/kg) were administered simultaneously, instead of protection, an enhancement of tremorogenic activity was seen. Although the exact mechanism of this drug interaction is far from clear, a multireceptor involvement (i.e. opioid, dopaminergic and cholinergic type) in the modulation of tremorine-induced tremors in mice has been speculated.
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