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  • Title: Electrochemiluminescence biosensor for cardiac troponin I with signal amplification based on a MoS2@Cu2O-Ag-modified electrode and Ce:ZnO-NGQDs.
    Author: Wang B, Wang C, Li Y, Liu X, Wu D, Wei Q.
    Journal: Analyst; 2022 Oct 24; 147(21):4768-4776. PubMed ID: 36149312.
    Abstract:
    Cardiac troponin I (cTnI) is one of the structural subunits of cardiac troponin complexes and a significant biomarker of acute myocardial infarction (AMI). Therefore, a sensitive detection of cTnI in the early stages is of great significance. Here, a sensitive sandwiched electrochemiluminescence (ECL) immunosensor was built for the detection of cTnI, where molybdenum disulfide@cuprous oxide-silver nanoparticles (MoS2@Cu2O-Ag) immobilized cTnI the capture antibody (Ab1), and cerium-doped zinc oxide@nitrogen-doped graphene quantum dots (Ce:ZnO@NGQDs) loaded the signal antibody (Ab2). The MoS2@Cu2O-Ag nanoparticles not only indicated excellent electroconductivity and biocompatibility but also provided a large specific surface. Ce:ZnO as a co-reaction accelerator can convert the Ce4+ ↔ Ce3+ reaction and might increase the rate of electron exchange to accomplish signal enhancement. Under optimum conditions, the sensor possessed a wide linear range from 10 pg mL-1 to 100 ng mL-1, and the LOD was 2.90 fg mL-1 (S/N = 3). In addition, the sensor plays a good role in serum detection, indicating that it has potential for application in the detection of biomolecules.
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