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  • Title: Effects of imipramine on depression and obsessive-compulsive symptoms.
    Author: Foa EB, Steketee G, Kozak MJ, Dugger D.
    Journal: Psychiatry Res; 1987 Jun; 21(2):123-36. PubMed ID: 3615688.
    Abstract:
    Most of the controlled studies on the efficacy of medical treatments of obsessive-compulsive disorder (OCD) have involved clomipramine, a tricyclic antidepressant reputed to have anti-obsessional properties. To test the possibility that the drug's antidepressant action mediates the reduction of obsessive-compulsive symptoms, we treated 37 OCD patients with imipramine (mean dose = 233 mg/day) or placebo for 6 weeks and assessed improvement on both obsessive-compulsive and depressive symptoms. Imipramine reduced depression in highly depressed OCD patients, but did not affect obsessive-compulsive symptoms in these or in less depressed patients.
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