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  • Title: [Characterization of an inhibitor of glucose-6-phosphate dehydrogenase].
    Author: Rodríguez-Torres AM, Villamarín A, Carballal C, Vázquez-Illánez MD, Ramos-Martínez JI.
    Journal: Rev Esp Fisiol; 1987 Mar; 43(1):7-11. PubMed ID: 3616114.
    Abstract:
    A strong inhibitor of G6PDH has been detected in rat liver homogenates. The inhibitor, isolated by ultrafiltration methods, proved to be very stable under incubation with trypsin and high temperatures. Gel-filtration through Sephadex G-75 showed it to have a molecular weight of 3,500 daltons, though perchloric acid treatment produced a light form of 900 daltons. Both forms of inhibitor act as competitive inhibitor with respect to G6P and exhibit non-competitive inhibition pattern with respect to NADP+. Physical and kinetic properties, and the increase of G6PDH activity at low NADP+ concentrations, in the presence of NADPH and inhibitor or palmitoyl-CoA, in relation to the G6PDH activity in presence of NADPH, lead to the identification of the low-molecular weight inhibitor as palmitoyl-CoA.
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