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  • Title: Autoantibodies to acrosomal antigens of spermatozoa in vasectomized mice.
    Author: Kosuda LL, Bigazzi PE.
    Journal: Invest Urol; 1978 Sep; 16(2):140-1. PubMed ID: 361627.
    Abstract:
    A total of 102 mice from seven different inbred strains were vasectomized or sham vasectomized. Sera from these animals were collected before vasectomy and at 7 and 10 months after the operation. Indirect immunofluorescence on sperm smears showed that 26 per cent of vasectomized mice had antibodies to arosomal antigens of spermatozoa. This response was restricted to three of seven strains. None of the sera obtained from animals before vasectomy or from sham-vasectomized control mice contained similar antibodies. The production of autoantibodies to spermatozoal antigens was evaluated in a total of 102 vasectomized or sham vasectomized mice from 7 different inbred strains. Sera was collected from these animals before vasectomy and at 7 and 10 months after the procedure. None of the 24 mice killed at 7 or months after vasectomy demonstrated gross morphologic alterations or the presence of sperm granulomas. However, antibodies to acrosomal antigens of spermatozoa were present in 26% of vasectomized mice. This response was restricted to 3 strains, with positive reactions noted in 78% of C57L/J, 67% of DBA/lJ, and 30% of C57B1/6 mice. None of the sera obtained from animals before vasectomy or from sham-vasectomized control mice contained similar antibodies. The development of antibodies to spermatozoa has been a consistent result of vasectomy in rats, rabbits, guinea pigs, monkeys, and humans. The potential danger of these antibodies to the health of human men needs further investigation. Particular attention should be given to the possible role of genetic predisposition to immune responses to spermatozoal antigens and immunologically mediated tissue damage.
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