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  • Title: Microsomal metabolism of pyrrolizidine alkaloids: N-oxidation of seneciphylline and senecionine.
    Author: Ramsdell HS, Buhler DR.
    Journal: Toxicol Lett; 1987 Aug; 37(3):241-9. PubMed ID: 3617098.
    Abstract:
    In vivo pretreatment of rats with phenobarbital or beta-naphthoflavone reduced the specific activity of microsomal pyrrolizidine alkaloid N-oxide formation. Heat pretreatment of microsomes under conditions intended to selectively inactivate the flavin-containing monooxygenase did not lower the rate of N-oxidation. Incubation in the presence of cytochrome P-450 inhibitors diminished the microsomal formation of N-oxide. The observations are consistent with the hypothesis that pyrrolizidine alkaloid N-oxidation
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