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  • Title: [Delayed-type hypersensitivity reaction induced in mice by the administration of an inactivated influenza vaccine].
    Author: Shpiliuk F, Shapiro NI, Polianskia NIu, Guskin IaR, Suhinin VP.
    Journal: Virologie; 1987; 38(2):127-33. PubMed ID: 3617497.
    Abstract:
    The conditions of delayed-type hypersensitivity induction following immunization with an inactivated influenza vaccine in BALB/c and CBA/H mice treated with cyclophosphane were studied. The results showed that the delayed-type hypersensitivity reaction had no type specificity when revealing preparation injected to immunized mice is a vaccine prepared with chorioallantoic fluid, but it is specific when a tissue vaccine is used. The use of inactivated influenza viruses cultivated on different cell-types for sensitization and revelation of the hypersensitivity state allowed to evaluate the level of the delayed-type hypersensitivity induced by untreated virus.
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