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  • Title: Two New Eremophilane-Type Sesquiterpenoids from Ligularia sagitta.
    Author: Chen WH, Yang HY, Wang YX, Wen ML, Yang ZD, Chen JJ.
    Journal: Chem Biodivers; 2022 Nov; 19(11):e202200762. PubMed ID: 36177989.
    Abstract:
    Two new eremophilane-type sesquiterpenoids, sagittacins F and G (1 and 2), together with one known isomer of sagittacin F (3) were isolated from the leaves and stems of Ligularia sagitta. Their structures were elucidated by interpretation of spectroscopic data and the absolute configurations of 1 and 3 were determined by X-ray spectroscopy. Compound 1 belongs to a rare class of eremophilane-type sesquiterpenoid featuring an α-oriented hydroxy group at C-1. A nitric oxide (NO) production inhibitory assay was applied to evaluate their anti-inflammatory activities by using LPS-induced RAW 264.7 cells. Compounds 2 and 3 exhibited modest NO production inhibitions with IC50 values of 45.15±2.72 and 49.83±2.34 μM, respectively.
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