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  • Title: [Assay of clomipramine and its demethylated derivative by liquid chromatography].
    Author: Guyon F, Ni P, Jezequel M, Dupeyron JP.
    Journal: Ann Biol Clin (Paris); 1987; 45(2):157-9. PubMed ID: 3619139.
    Abstract:
    Clomipramine and desmethylclomipramide are determined on 1 ml of human blood plasma, after extraction with hexane and high-performance liquid chromatography using a cyanopropyl silane column and UV detection at 280 nm. Imipramine and desipramine are used as internal standards. The methods allow detection limits of 5 micrograms/l; 15.9 nmol/l (clomipramine) to 10 micrograms/l; 33.2 nmol/l (desmethylclomipramine). The precision of the method at clomipramine concentrations of 0.05 to 0.2 mg/l was indicated by a coefficient of variations less than 6% for clomipramine and less than 7% for desmethylclomipramine.
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