These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis, Crystal Structures and Urease Inhibition of Mononuclear Copper(II) and Nickel(II) Complexes with Schiff Base Ligands.
    Author: Jiang J, Liang P, Yu H, You Z.
    Journal: Acta Chim Slov; 2022 Sep 26; 69(3):629-637. PubMed ID: 36196808.
    Abstract:
    Three mononuclear copper(II) and nickel(II) complexes, [Cu(L1)(NCS)(CH3OH)] (1), [Cu(L2)(NCS)] (2) and [Ni(L2)(N3)] (3), where L1 and L2 are the monoanionic forms of the Schiff bases N'-(pyridin-2-ylmethylene)picolinohydrazide (HL1) and 4-methyl-2-(((pyridin-2-ylmethyl)imino)methyl)phenol (HL2), have been prepared and characterized by elemental analysis, IR and UV-Vis spectroscopy, as well as single crystal X-ray diffraction studies. The Cu atom in complex 1 is in a square pyramidal coordination, with the three N atoms of the ligand L and the N atom of the thiocyanate ligand in the basal plane, and with the methanol O atom at the apical position. The Cu and Ni atoms in complexes 2 and 3 are in square planar coordination, with the three donor atoms of the Schiff base ligands and the terminal N atoms of thiocyanate and azide ligands. Complexes 1 and 2 inhibit the Jack bean urease with IC50 value of 0.33±0.12 and 0.39±0.10 μmol L-1, respectively. Molecular docking study was performed to investigate the interaction between the complexes and the enzyme.
    [Abstract] [Full Text] [Related] [New Search]