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  • Title: [Effect of oxaloacetic acid on hydrogen-calcium metabolism in mitochondria].
    Author: Asrarov MI, Gagel'gans AI, Tashmukhamedov BA.
    Journal: Biofizika; 1987; 32(3):454-7. PubMed ID: 3620523.
    Abstract:
    It has been shown by using o-phthalic acid--a concurrent inhibitor of the transport of oxalacetic acid in mitochondria that the effect of the latter on the mechanism of 2H+/Ca2+-metabolism is realized at the inner side of the inner mitochondrial membrane. Oxalacetic acid was shown to induce not only the release of Ca2+ ions but also those of strontium and manganese accumulated in the mitochondria (100-150 nmol/mg of protein). Mechanism of the effect of oxalacetic acid on permeability of the mitochondria membranes are discussed.
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