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  • Title: Multimodal responses of preoptic and anterior hypothalamic neurons to thermal and nonthermal homeostatic parameters.
    Author: Hori T, Kiyohara T, Nakashima T, Shibata M, Koga H.
    Journal: Can J Physiol Pharmacol; 1987 Jun; 65(6):1290-8. PubMed ID: 3621078.
    Abstract:
    The hypothesis that thermosensitive neurons in the preoptic anterior hypothalamic nuclei (POAH) have a principal role in central thermoregulation is based on numerous findings, suggesting correlations between the activity of thermosensitive neurons and thermoregulatory responses. Such relationships have been observed during thermal (local and peripheral) and pharmacological stimulation, during modulation of neural inputs from extra-POAH brain regions, and during actual thermoregulatory responses. Recent studies using in vitro slice preparations and conscious animals have revealed that 40-70% of POAH thermosensitive neurons respond to nonthermal homeostatic parameters such as local osmolality, blood pressure, and nonthermal emotional stimuli. About two-thirds of the POAH thermosensitive neurons, which responded in monkeys during bar press thermoregulatory tasks, changed their activity during bar press feeding behavior. A high degree of convergence of thermal and nonthermal homeostatic signals on the POAH neurons, together with abundant neural connections between the POAH and divergent areas of the brain, suggests that POAH thermosensitive neurons may be involved in the coordination of thermoregulation and nonthermal autonomic and behavioral responses controlled from the hypothalamus.
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