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  • Title: In vivo nutrient uptake by head and neck cancers.
    Author: Richtsmeier WJ, Dauchy R, Sauer LA.
    Journal: Cancer Res; 1987 Oct 01; 47(19):5230-3. PubMed ID: 3621209.
    Abstract:
    The arteriovenous uptake differences for glucose, lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate were measured in vessels across squamous cell carcinomas in ten selected patients with tumors of the head and neck. All tumors measured took up glucose, pyruvate, beta-hydroxybutyrate, and acetoacetate. They could either produce, take up, or maintain a constant level of lactate. These tumors demonstrate a heterogeneous affinity for various metabolites, including ketone bodies which are elevated in the nutritionally depleted, tumor-burdened patient.
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