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  • Title: Direct α-C-H Alkylation of Structurally Diverse Alcohols via Combined Tavaborole and Photoredox Catalysis.
    Author: Sun T, Jin R, Yang Y, Jia Y, Hu S, Jin Y, Wang Q, Li Z, Zhang Y, Wu J, Jiang Y, Lv X, Liu S.
    Journal: Org Lett; 2022 Oct 21; 24(41):7637-7642. PubMed ID: 36218287.
    Abstract:
    Herein, we report a method that uses antifungal tavaborole as a co-catalyst for direct α-C-H alkylation of structurally diverse alcohols through photoredox catalysis. The protocol features mild conditions, remarkable scope, and wide functional group tolerance, which allows for the construction of a wide array of highly functionalized alcohols, including homoserine derivatives and C-glycosyl amino acids. We also demonstrate the synthetic applications of this methodology to the late-stage functionalization of pharmaceuticals and natural products.
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