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  • Title: NiH-Catalyzed Proximal-Selective Hydroamination of Unactivated Alkenes with Anthranils.
    Author: Cui Y, Gao Y, Zhao W, Luo Y, Xie H, Huo Y, Hu XQ.
    Journal: J Org Chem; 2022 Nov 04; 87(21):14861-14869. PubMed ID: 36219840.
    Abstract:
    The regioselective hydroamination of unactivated alkenes is a long-standing challenge in organic synthesis. Herein, we report a NiH-catalyzed proximal-selective hydroamination of unactivated alkenes with 8-aminoquinoline (AQ) as a bidentate auxiliary and anthranils as aminating reagents. A wide range of primary aryl amines bearing an ortho-carbonyl group were installed in both terminal and internal unactivated alkenes, delivering a variety of valuable β- and γ-amino acid building blocks, respectively, with excellent regiocontrol. The utility of this transformation was further demonstrated by the conversion of the multifunctionalized aryl amines into useful N-heterocycles.
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