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  • Title: [Treatment of acute intermittent porphyria with a new protein-bound lyophilized hematin].
    Author: Fuchs T, Ippen H.
    Journal: Dtsch Med Wochenschr; 1987 Aug 21; 112(34):1302-5. PubMed ID: 3622268.
    Abstract:
    Hematin (iron-III-protoporphyrin 9) has been used for several years in the treatment of acute attacks of inducible porphyrias. Three patients were treated with a new, albumin-bound lyophilized hematin preparation (manufactured by Behringwerke). In all patients it achieved a reduction in the urine of the porphyrin precursors porphobilinogen and 5-aminolevulin acid. In two patients the clinical symptoms were clearly improved, while a third patient died with tetraparesis. Hematin administration proved superior to the preceding glucose treatment. No abnormality of clotting or thrombophlebitis was detectable after hematin infusion.
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