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  • Title: Knockdown of a Nicotinic Acetylcholine Receptor Subunit Gene Bdorβ1 Decreases Susceptibility to Oxa-Bridged trans- instead of cis-Nitromethylene Neonicotinoid Insecticides in Bactrocera dorsalis.
    Author: Yuan GR, Chen ML, Peng ML, Lei W, Meng LW, Dou W, Wang JJ.
    Journal: J Agric Food Chem; 2022 Oct 26; 70(42):13554-13562. PubMed ID: 36224100.
    Abstract:
    Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate the fast action of acetylcholine in synaptic cholinergic transmissions. Insect nAChRs are the target of several classes of insecticides. Here, the full-length cDNA encoding a nAChR beta1 subunit (Bdorβ1) was identified and characterized from a destructive pest, Bactrocera dorsalis. The amino acid sequence of Bdorβ1 shows high identities to other insect nAChRs β1 subunits. Double injection of dsBdorβ1 reduced the expression of Bdorβ1 and in turn significantly decreased susceptibility to oxa-bridged trans- instead of cis-nitromethylene neonicotinoids. Our results support the involvement of Bdorβ1 in the susceptibility of B. dorsalis to oxa-bridged trans- instead of cis-nitromethylene neonicotinoids and imply that these two classes of neonicotinoids might be acting at different nAChR subtypes.
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