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  • Title: Picrotoxin but not bicuculline antagonizes 5-hydroxytryptamine-induced inhibition of cerebellar Purkinje neurons.
    Author: Lee M, Strahlendorf JC, Strahlendorf HK.
    Journal: Exp Neurol; 1987 Sep; 97(3):577-91. PubMed ID: 3622711.
    Abstract:
    The inhibitory effects of iontophoretically applied serotonin (5-hydroxytryptamine) on Purkinje cells were examined in the presence of the GABA antagonists picrotoxin and bicuculline in in vivo and in vitro cerebellar preparations. Continuous application of the GABA-mediated chloride ionophore antagonist, picrotoxin, at currents that induced significant antagonism of GABA-elicited inhibition of Purkinje cells decreased the inhibitory effects of serotonin significantly in the same neurons. Bicuculline, an antagonist of GABA receptors, exerted different actions on serotonin-mediated inhibition of Purkinje cells. Continuous iontophoretic applications of bicuculline antagonized the inhibitory effects of GABA on Purkinje cells significantly, but failed to induce significant attenuation of serotonin-mediated inhibition. The inhibitory effects of serotonin on Purkinje cells were examined also in the presence of nipecotic acid, an inhibitor of GABA reuptake, and a low Ca2-high Mg2+ medium, which blocks synaptic transmission. Under these circumstances, serotonin-mediated inhibitions were not influenced significantly, indicating that its inhibitory effects do not involve release or reuptake of GABA. These results indicate that there might be a linkage between the actions of serotonin and GABA.
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