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  • Title: Immunopathogenesis of chronic periapical lesions. A review.
    Author: Torabinejad M, Bakland LK.
    Journal: Oral Surg Oral Med Oral Pathol; 1978 Nov; 46(5):685-99. PubMed ID: 362319.
    Abstract:
    The pathogenesis of periapical lesions has not been fully elucidated. Currently, the possibility of its being an immunologic phenomenon is receiving much attention. This article presents a review of the literature concerning immunologic reactions which may involve periapical lesions. It appears that antigen-antibody complexes and IgE-mediated reactions can initiate preliminary changes in periapical tissues. It is also likely that delayed hypersensitivity participates in the perpetuation and progression of periapical disease.
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